IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/rawls

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Developmental history of the mammalian oocyte: insight from mouse mutations
Show Less
1 Department of Biology, Molecular and Cellular Biology Graduate Program, Arizona State University, AZ, USA

Academic Editor: David Capco

Front. Biosci. (Landmark Ed) 2001, 6(3), 1173–1185; https://doi.org/10.2741/rawls
Published: 1 October 2001
(This article belongs to the Special Issue Molecular and biochemical control of preimplantation development)
Abstract

Growth and differentiation of the mammalian oocyte is regulated with the coordinate development of the granulosa cells. The complex signaling pathways that regulate the growth and development of mammalian oocytes are beginning to be elucidated through the use of gene targeting. These technologies have provided new insight into the roles of specific genes during the development of the germ cells and gonads, as well as post-pubertal development of oocytes. In many cases, these studies have resulted in a new understanding of the function of certain genes, in others they have provided new genes and pathways to be studied in mammalian reproductive biology. Ultimately, these studies will shed light on human genetic disease and infertility.

Share
Back to top