IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/mackman

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Gene targeting in hemostasis. tissue factor
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1 The Scripps Research Institute, Depts. of Immunology & Vascular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Front. Biosci. (Landmark Ed) 2001, 6(3), 208–215; https://doi.org/10.2741/mackman
Published: 1 February 2001
Abstract

Tissue factor (TF) is the primary cellular initiator of blood coagulation. At sites of vascular injury, formation of a TF:FVIIa complex leads to the generation of FXa, thrombin and the deposition of fibrin to limit hemorrhage. In contrast to its beneficial role in hemostasis, TF initiates life-threatening intravascular thrombosis in sepsis, atherosclerosis and cancer. More recently, TF has been proposed to play a role in other biological processes, including tumor-associated angiogenesis, metastasis and inflammation. Indeed, gene targeting of TF resulted in embryonic lethality, which appeared to be due to a defect in the yolk sac vasculature.

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