IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/eliyahu

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
PKC in eggs and embryos
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1 Department of Embryology, Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv 69978 Tel-Aviv, Israel
Front. Biosci. (Landmark Ed) 2001, 6(3), 785–791; https://doi.org/10.2741/eliyahu
Published: 1 July 2001
Abstract

After a spermatozoon enters the egg, rapid processes such as the cortical granules exocytosis (CGE) occur. Other, later processes are observed as well, and they include resumption of the second meiotic division, second polar body (PBII) extrusion and rearrangement of the DNA inside the pronuclei (PN). The above mentioned biochemical processes involve signal transduction pathways that are well known in other cell systems, and require mediation of second messengers like Ca2+ and diacylglycerol (DAG) which are protein kinase C (PKC) activators. The present review, based upon recently published studies, raises the possibility of PKC involvement in fertilization and in early developmental stages of the mammalian embryo.

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