IMR Press / FBL / Volume 5 / Issue 3 / DOI: 10.2741/renkema

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Interactions of HIV-1 NEF with cellular signal transducing proteins
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1 Institute of Medical Technology, University of Tampere, FIN-33101, Tampere, Finland
2 Dept. of Clinical Chemistry, Tampere University Hospital, P.O. Box 2000, FIN-33521, Tampere, Finland
Front. Biosci. (Landmark Ed) 2000, 5(3), 268–283;
Published: 1 February 2000

Nef is a 27 - 34 kD myristoylated protein unique to primate lentiviruses. A functional Nef gene is important for development of high viremia and simian AIDS in SIV infected rhesus macaques (1). In a transgenic mouse model expression of Nef protein alone when expressed under a CD4-promoter is sufficient to cause an AIDS like disease (2). A critical role for Nef in development of AIDS in humans is suggested by the observation that some individuals with a long-term nonprogressive HIV-1 infection are infected with viruses carrying naturally occurring Nef deletions (3-5). The mechanism of Nef action remains incompletely understood, but multiple lines of evidence point out to a role in modulation of cellular signaling pathways via physical and functional interactions with host cell proteins.

protein kinase
SH3 domain
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