IMR Press / FBL / Volume 5 / Issue 3 / DOI: 10.2741/hixon

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The control of mitosis
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1 Division of Cardiovascular Research, Department of Medicine, St. Elizabeth's Medical Center, Boston, MA 02135, USA
2 Department of Cardiovascular and Metabolic Diseases, Pfizer Central Research Division, Eastern Point Rd., Groton, CT 06340, USA
Academic Editor:Xavier Grana
Front. Biosci. (Landmark Ed) 2000, 5(3), 50–57; https://doi.org/10.2741/hixon
Published: 1 January 2000
(This article belongs to the Special Issue Eukaryotic cell cycle control)
Abstract

A precise coordination of multiple cell cycle events is required to ensure proper mitosis. Chromosome cohesion must be maintained until all chromosomes are attached to opposite poles of the mitotic spindle and aligned at the metaphase plate. At the onset of anaphase, the activity of separins contributes to the release of cohesins from chromosomes, allowing for the segregation of bivalents to opposite spindle poles. Separin activity is blocked by binding to a class of proteins known as securins, whose turnover at the metaphase-to-anaphase transition is triggered by the Anaphase Promoting Complex or cyclosome. The mitotic spindle cell cycle checkpoint coordinates the timing of these events and acts as input mechanism for DNA damage/stress pathways. Failure of this precise network leads to genomic instability and/or cell death.

Keywords
Cohesin
Separin
Securin
Anaphase Promoting Complex
Mitotic Spindle Cell Cycle Checkpoint
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