IMR Press / FBL / Volume 5 / Issue 3 / DOI: 10.2741/A494

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Pathogenesis and treatment of HIV-1 infection: recent developments (Y2K update)
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1 Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester NY 14642, USA
2 Cancer Center, University of Rochester Medical Center, Rochester NY, USA
Academic Editor:Adriana Heguy
Front. Biosci. (Landmark Ed) 2000, 5(3), 30–49; https://doi.org/10.2741/A494
Published: 1 January 2000
(This article belongs to the Special Issue New and emerging targets for antiviral therapy)
Abstract

Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS). The pathogenesis of HIV-1-induced disease is complex and characterized by the interplay of both viral and host factors, which together determine the outcome of infection. An improved understanding of the pathogenic mechanisms of AIDS, combined with recent insights into the dynamics of viral infection may provide powerful new opportunities for therapeutic intervention against this virus.

Keywords
Human immunodeficiency virus type-1 (HIV1)
Acquired immunodeficiency syndrome (AIDS)
antiretrovirals
Highly activte antiretroviral therapy (HAART)
Vaccine
Pathogenesis
Disease progression
Review
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