IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/poole

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
An introduction to the pathophysiology of osteoarthritis
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1 Joint Diseases Laboratory, Shriners Hospitals for Children and Division of Surgical Research, Department of Surgery, McGill University 1529 Cedar Avenue, Montreal, Quebec H3G 1A6, Canada
Academic Editor:Charles Malemud
Front. Biosci. (Landmark Ed) 1999, 4(4), 662–670; https://doi.org/10.2741/poole
Published: 15 October 1999
(This article belongs to the Special Issue Fundamental pathways in osteoarthritis)
Abstract

Osteoarthritis involves the degeneration of articular cartilage together with changes in subchondral bone and limited intra-articular inflammation. In this chapter these changes are reviewed at the tissue, cell and molecular levels to reveal the complexity of a process which involves multiple changes in joint structure and turnover.

Keywords
Osteoarthritis
Cartilage
Bone
Inflammation
Cytokines
Proteinases
Degradation
Synthesis
Review
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