IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/pawelec

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
T cells and aging (update february 1999)
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1 University of Tubingen, Tubingen, FRG
2 UCLA School of Medicine, Los Angeles, CA, USA
3 Calogero Caruso, University of Palermo, Palermo, Italy
4 Ed Remarque, University of Leiden, Leiden, Holland
5 Yvonne Barnett, University of Ulster, Coleraine, Northern Ireland
6 Rafael Solana, University of Córdoba, Córdoba, Spain
Academic Editor:Graham Pawelec
Front. Biosci. (Landmark Ed) 1999, 4(4), 216–269; https://doi.org/10.2741/pawelec
Published: 1 March 1999
(This article belongs to the Special Issue T cell immunosenescence)
Abstract

Deterioration of the immune system with aging ("immunosenescence") is believed to contribute to morbidity and mortality in man due to the greater incidence of infection, as well as possibly autoimmune phenomena and cancer in the aged. Dysregulation of T cell function is thought to play a critical part in these processes. Factors contributing to T cell immunosenescence may include a) stem cell defects, b) thymus involution, c) defects in antigen presenting cells (APC), d) aging of resting immune cells, e) disrupted activation pathways in immune cells, f) replicative senescence of clonally expanding cells. This review aims to consider the current state of knowledge on the scientific basis for and potential clinical relevance of those factors in immunosenescence.

Keywords
T cells
Aging
Immunosenescence
Immune Response
Immunogerontology
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