IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/niemela

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress
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1 Department of Clinical Chemistry, University of Oulu, FIN-90220 Oulu, and EP Central Hospital Laboratory, Seinäjoki, Finland
Front. Biosci. (Landmark Ed) 1999, 4(4), 506–513; https://doi.org/10.2741/niemela
Published: 1 June 1999
Abstract

A number of systems that generate oxygen free radicals and reactive aldehydic species are activated by excessive ethanol consumption. Recent studies from human alcoholics and from experimental animals have indicated that acetaldehyde and aldehydic products of lipid peroxidation, which are generated in such processes, can bind to proteins forming stable adducts. Adduct formation may lead to several adverse consequences, such as interference with protein function, stimulation of fibrogenesis, and induction of immune responses. The presence of protein adducts in the centrilobular region of the liver in alcohol abusers with an early phase of histological liver damage indicates that adduct formation is one of the key events in the pathogenesis of alcoholic liver disease. Dietary supplementation with fat and/or iron strikingly increases the amount of aldehyde-derived epitopes in the liver together with promotion of fibrogenesis.

Keywords
alcoholic liver disease
fibrogenesis
lipid peroxidation
acetaldehyde
iron
immunohistochemistry
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