IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/masai

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
CDC7 kinase complex as a molecular switch for DNA replication
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1 Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan and CREST, Japan Science Technology
Academic Editor:Hisao Masai
Front. Biosci. (Landmark Ed) 1999, 4(4), 834–840;
Published: 1 December 1999
(This article belongs to the Special Issue DNA replication mechanisms and regulation)

Cdc7 kinase and its activator Dbf4 protein, originally identified in budding yeast Saccharomyces cerevisiae, are widely conserved in eukaryotes including fission yeast and human. Dbf4-related activators bind and stimulate kinase activity of Cdc7-like catalytic subunit. Its kinase activity is cell cycle-regulated, mainly through availability of the activation subunit whose level increases at G1/S boundary and is maintained at a high level throughout S phase. MCM2 protein is among physiologically important substrates. Genetic studies in fission yeast indicate that Cdc7-related kinase complex also functions in meiosis, uninduced mutagenesis, DNA replication checkpoint signaling and maintenance of chromatin structures during S phase.

Initiation of DNA replication
Serinethreonine kinase
G1/ S transition
DNA replication Checkpoint control
Cell cycle
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