IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/martel

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cytokines and their role in the pathophysiology of osteoarthritis
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1 University of Montréal, Director - Osteoarthritis Research Unit, Centre hospitalier de l’Université de Montréal, Hôpital NotreDame, Montréal, Québec, Canada
2 University of Montréal, Centre hospitalier de l’Université de Montréal, Hôpital NotreDame, Montréal, Québec, Canada
3 University of Montréal, Head - Rheumatic Disease Unit, Director - Osteoarthritis Research Unit, Centre hospitalier de l’Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada
Academic Editor:Charles Malemud
Front. Biosci. (Landmark Ed) 1999, 4(4), 694–703; https://doi.org/10.2741/martel
Published: 15 October 1999
(This article belongs to the Special Issue Fundamental pathways in osteoarthritis)
Abstract

The specific causative agent of the pathological process of osteoarthritis (OA) has not yet been identified, however, episodic inflammation at the clinical stage is now a well documented phenomenon and believed to be involved in the disease progression. Interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are the predominant proinflammatory cytokines synthesized during the OA process. Other cytokines having proinflammatory properties or catabolic factors could also contribute to this pathological condition, and those having antiinflammatory properties may be able to counteract the negative effects of the former on the disease process. In this chapter, we will review cytokine interactions and their modulatory effects on joint articular tissue metabolism, including their stimulatory and/or inhibitory actions, and their potential relevance to OA. We will also briefly survey the major biological factors, in relation to cytokines, that look promising for future therapeutic approaches.

Keywords
OA
Proinflammatory Cytokines
Antiinflammatory Cytokines
Cytokine Antagonists
Nitric Oxide
Review
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