IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/jaszewsk

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Aging and cancer of the stomach and colon
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1 John D. Dingell VA Medical Center, Detroit, Michigan 48201, USA
2 Department of Internal Medicine, Biochemistry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
3 Department of Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
4 Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Academic Editor:Adhip Majumdar
Front. Biosci. (Landmark Ed) 1999, 4(4), 322–328; https://doi.org/10.2741/jaszewsk
Published: 15 March 1999
(This article belongs to the Special Issue Gastrointestinal growth and carcinogenesis)
Abstract

Although the incidence of most human malignancies including cancer of the gastrointestinal tract increases dramatically with advancing age, the precise role of aging in that increase remains a matter of continued controversy. Many probable explanations for the age-related rise in cancer incidence have been offered including altered carcinogen metabolism and the cumulative effects of protracted exposure to cancer-causing agents. Neoplasia of the stomach or colon is a multi-stage process with hyperproliferation being central to the initiation of carcinogenesis. Since aging is associated with increased gastrointestinal mucosal cell proliferation, the possibility that aging itself may render target cells more susceptible to carcinogenic transformation continues to be an area of intense interest and study. This review will examine the evidence for age-related alterations in the structural and functional properties of the gastric and colonic mucosa in an effort to further elucidate the potential mechanisms of carcinogenesis which may be involved during the aging process.

Keywords
Cancer
Gastrointestinal
Carcinogenesis
Tyrosine Kinase
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