IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/graves

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts
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1 Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
2 Department of Endodontics, Boston University School of Dental Medicine, Boston, MA 02118, USA
3 Department of Medicine, University of Texas Health Science Center, San Antonio, Texas,USA
Academic Editor:Kenth Gustafsson
Front. Biosci. (Landmark Ed) 1999, 4(4), 571–580;
Published: 1 July 1999

Chemokines are low molecular weight secretory proteins that function principally as stimulators of leukocyte recruitment. There are four defined chemokine subfamilies based on their primary structure, CXC, CC, C and CX3C. Members of the CC chemokine subfamily, a such as monocyte chemoattractant protein 1 (MCP-1) are chemotactic for monocytes and other leukocyte subsets. Because monocytes produce factors that regulate bone formation or resorption, such as PDGF, IL-1 or TNF, chemokines that initiate their recruitment are likely to be important in regulating osseous metabolism. In the studies below, data is presented demonstrating mechanisms of MCP-1 expression in osteoblastic cells. These studies establish that MCP-1 is induced during osseous inflammation and in developmentally regulated bone remodelling, and is associated with enhanced monocyte recruitment when applied to osseous lesions.

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