IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/chailler

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Ontogeny of EGF receptors in the human gut
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1 Groupe du CRM sur le Développement Fonctionnel et la Physiopathologie du Tube Digestif, Département d'anatomie et de biologie cellulaire, Faculté de medecine, Université de Sherbrooke, Sherbrooke (Quebec), Canada
Academic Editor:Adhip Majumdar
Front. Biosci. (Landmark Ed) 1999, 4(4), 87–101; https://doi.org/10.2741/chailler
Published: 15 January 1999
(This article belongs to the Special Issue Gastrointestinal growth and carcinogenesis)
Abstract

Epidermal growth factor and related substances mediate their effects on epithelial cells through binding to high-affinity receptors (EGF-R) at their basolateral surface and it is hypothesized that this growth factor system play a major role in gut morphogenesis and maintenance. The current review emphasizes on analyzing the expression and the biochemical characteristics of EGF-R in human fetal gut segments and correlating the biological actions of EGF-R ligands. They appear to be primarily involved in the local regulation of epithelial cell proliferation in which EGF-R are abundant. Alternatively, EGF-R ligands exert some precocious maturative effects by increasing intestinal lactase activity and decreasing brush border hydrolases in colon while they down modulate the expression of segment-specific markers of terminal differentiation such as sucrase, trehalase and glucoamylase in the intestine and chief cell lipase in the stomach. Such effects are consistent with the identification of receptors at the surface of all epithelial cell types, illustrating the modulatory role of EGF on differentiated gut epithelial cells. Comparison with animal models illustrates similar biochemical properties of receptors and underlines physiological aspects specific to human gut development. The relevance for ligand heterogeneity is also discussed and tentatively associated with different delivery pathways or physiological responses.

Keywords
EGF receptor
EGF binding
Human fetal gut
Intestinal mucosa
Gastric mucosa
Cell proliferation
Brush border hydrolases
Gastric enzymes
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