IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/cary

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Focal adhesion kinase in integrin-mediated signaling
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1 Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
Academic Editor:Staffan Johansson
Front. Biosci. (Landmark Ed) 1999, 4(4), 102–113; https://doi.org/10.2741/cary
Published: 15 January 1999
(This article belongs to the Special Issue Integrins, cell migration and extracellular matrix)
Abstract

Integrins serve as adhesion receptors for extracellular matrix proteins and also transduce biochemical signals into the cell. These signaling events regulate such cellular processes as proliferation, apoptosis, migration and spreading. Focal adhesion kinase (FAK) is an important protein tyrosine kinase which mediates several integrin signaling pathways. Putative mechanisms of integrin-mediated FAK activation and localization to focal adhesions are discussed here. FAK interacts with a number of signaling and cytoskeletal proteins, including Src, phosphatidylinositol 3-kinase, Grb2, p130Cas and paxillin. Both the mechanisms and outcomes of these interactions are also presented. Finally, FAK's roles in the regulation of several integrin-mediated cellular events are discussed, including the promotion of cell migration, proliferation and spreading, and the prevention of cell apoptosis.

Keywords
Extracellular matrix (ECM)
Focal adhesion kinase (FAK)
Integrin
Signal transduction
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