IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/beaulieu

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Integrins and human intestinal cell functions
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1 MRC Group in Functional Development and Physiopathology of the Digestive Tract, Département d'anatomie et de biologie cellulaire, Faculté de médecine, Université de Sherbrooke, Sherbrooke, Qué, CanadaJ1H 5N4
Academic Editor:Adhip Majumdar
Front. Biosci. (Landmark Ed) 1999, 4(4), 310–321; https://doi.org/10.2741/beaulieu
Published: 15 March 1999
(This article belongs to the Special Issue Gastrointestinal growth and carcinogenesis)
Abstract

Integrins are a large family of cell-surface receptors involved in cell adhesion to the extracellular matrix. In epithelia, it is mainly the integrins belonging to the beta1 and beta4 classes that bind to basement membrane molecules such as the laminins and the type IV collagens. Beta1 and beta4 integrins regulate the assembly of adhesive junctions as well as the activation of various signaling pathways leading to the modulation of gene expression. In this review, I will discuss what is currently known about integrins in human intestinal epithelial cells. The interest in the intestinal cell model to analyze cell-matrix interactions will be delineated and the recent experimental evidence showing that these interactions can regulate cell proliferation and differentiation will be presented.

Keywords
Cell-matrix interactions
intestine
epithelium
integrins
extracellular matrix molecules
proliferation
differentiation
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