IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/A462

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Fundamental pathways in osteoarthritis: an overview
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1 Departments of Medicine & Anatomy, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106-4946, USA
Academic Editor:Charles Malemud
Front. Biosci. (Landmark Ed) 1999, 4(4), 659–661; https://doi.org/10.2741/A462
Published: 15 October 1999
(This article belongs to the Special Issue Fundamental pathways in osteoarthritis)
Abstract

Osteoarthritis (OA) is a significant world-wide health problem owing to the progressive and debilitating nature of the condition which results in high morbidity and a marked decrease in the quality of life. Significant advances in the medical and surgical management of OA have resulted from an understanding of the fundamental pathways governing the health and disease of synovial joint tissues. Continuing investigations into the nature of synovial joint pathophysiology at both the molecular and biochemical level should pave the way for the development of novel therapeutic strategies, including gene therapy and tissue engineering, in the treatment of the OA patient.

Keywords
Cartilage
Chondrocytes
Extracellular Matrix
Cytokines
Metalloproteinases
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