IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/A417

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Signal relays in the VEGF system
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1 Laboratoire de Biologie Moleculaire Eucaryote, CNRS UPR 9006, 118 Route de Narbonne, 31062 Toulouse cedex, France
Academic Editor:Andrius Kazlauskas
Front. Biosci. (Landmark Ed) 1999, 4(4), 141–152;
Published: 1 February 1999
(This article belongs to the Special Issue Signaling through protein kinase C)

A considerable progress has been made during the past years in elucidating the molecular actors of angiogenesis. Vascular endothelial growth factor turned out to represent the major inducer of angiogenesis. Optional splicing of its pre messenger RNA generates various isoforms which differ not only by their storage in the extracellular matrix but also by their signaling pathways. VEGF binds and activates two tyrosine kinase receptors called VEGFR1 and VEGFR2 and neuropilin-1. The elucidation of the transduction pathways of each receptor suggests that VEGFR1 mediates cell migration whereas VEGFR2 mediates cell proliferation. The construction of internal images of VEGF by the anti-idiotypic antibody strategy allowed us to determine that quiescent endothelial cells need to be activated by so far unknown factors to become competent to respond to mitogenic signals and acquire an angiogenic phenotype. The discovery of the mechanisms of action of the VEGF system has allowed the design of promising drugs which already entered the pre-clinical or clinical assays.

Extracellular matrix
Vascular Endothelial Growth Factor
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