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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Article
Is Alzheimer's disease associated with a decreased intracellular level of calcium?
Ming Chen1,*
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1
Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, Florida 33612, and
Medical Research Service (151), VA Medical Center, Bay Pines, Florida 33744, USA
Front. Biosci. (Landmark Ed) 1998, 3(6), 1–2;
https://doi.org/10.2741/A385
Submitted: 30 March 1998 | Accepted: 1 April 1998 | Published: 1 April 1998
Abstract
Several biochemical events underlying the hallmark lesions of the Alzheimer's disease are calcium-dependent processes, and appear to be inactivated during the disease progression. Therefore, it is reasonable to propose that, contrary to the current beliefs, there is a deficit in the level of intracellular calcium in the early phase of this disease process.
Keywords
Alzheimer's disease
Calcium
Neurotransmission