Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Is Alzheimer's disease associated with a decreased intracellular level of calcium?
Several biochemical events underlying the hallmark lesions of the Alzheimer's disease are calcium-dependent processes, and appear to be inactivated during the disease progression. Therefore, it is reasonable to propose that, contrary to the current beliefs, there is a deficit in the level of intracellular calcium in the early phase of this disease process.