IMR Press / FBL / Volume 3 / Issue 5 / DOI: 10.2741/A382

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Gene therapy and pancreatic cancer
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1 Departments of Surgical Oncology (ASP, MB, DBE) and Thoracic and Cardiovascular Surgery (JAR), The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Front. Biosci. (Landmark Ed) 1998, 3(5), 230–237; https://doi.org/10.2741/A382
Published: 1 November 1998
Abstract

Adenocarcinoma of the pancreas is associated with a short survival due to frequent delays in diagnosis and the lack of effective systemic therapies. Advances in understanding the molecular basis of pancreatic cancer have allowed identification of molecular targets which are amenable to therapeutic intervention. Such targets include p53, K-ras, p16, and DPC-4. Gene therapy involves the transfer of genetic constructs which alter the neoplastic potential of the cancer cell. Vectors used in gene transfer include viral and non-viral methods. Presently, gene therapy of pancreatic cancer is limited to pre-clinical studies using in vitro and in vivo models. However, the initial results from these pre-clinical studies have been encouraging and will form the basis for clinical studies of gene transfer in patients with pancreatic cancer.

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