Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Regulation of alpha1-adrenergic receptors (alpha1ARs) is a rapidly expanding field of study due to the involvement of these receptors in several human diseases. For example, upregulation of alpha1aAR mRNA/protein with agonist exposure has been implicated in myocardial hypertrophy. In order to understand mechanisms underlying these findings, initial studies of human alpha1aAR transcription have been completed and the primary promoter characterized. This review summarizes current knowledge regarding human alpha1aAR gene transcription and compares characteristics with other adrenergic receptor genes.