IMR Press / FBL / Volume 3 / Issue 3 / DOI: 10.2741/A259

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Use of genetically engineered mice as models for exploring the role of oxidative stress in neurodegenerative diseases
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1 Division of Biogerontology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA
Front. Biosci. (Landmark Ed) 1998, 3(3), 8–16; https://doi.org/10.2741/A259
Published: 25 March 1998
Abstract

A growing body of evidence has suggested that oxidative stress may play a major role in the degeneration of neurons associated with several neurological diseases of aging including ALS, Parkinson's, and Alzheimer's disease; this has been the topic of numerous previous reviews and opinion papers (e.g. 1-10). The ability to construct genetically engineered mouse lines containing targeted mutations has done much to aid in the assessment of the role of reactive oxygen species (ROS) in both the initiation as well as the progression of these diseases and has markedly advanced research in the field. Most importantly, the creation of genetic animal models has strengthened the argument that antioxidants may be a useful therapy in the treatment of these types of disorders.

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