Background: Infliximab is a human-murine chimeric monoclonal IgG
antibody against tumor necrosis factor that is used in combination with
methotrexate for the treatment of moderate to severe rheumatoid arthritis (RA).
The trough concentration of serum infliximab required to control disease activity
in RA is
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Original Research
The Impact of Early Optimization of Infliximab Blood Concentrations >1 μg/mL on Therapeutic Effectiveness in Rheumatoid Arthritis
Yuji Nozaki1,*, Takuya Kotani2, Tohru Takeuchi2, Toshihiko Hidaka3, Hirofumi Miyake4, Kazuhiro Hatta4, Yoichi Kurosawa5,6, Masanori Sudo5,6, Satoshi Ito6, Koji Kinoshita1, Itaru Matsumura1
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1
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-sayama, 589-8511 Osaka, Japan
2
Department of Internal Medicine IV, Division of Rheumatology, Osaka Medical and Pharmaceutical University, Takatsuki, 569-8686 Osaka, Japan
3
Institute of Rheumatology, Miyazaki Zenjinkai Hospital, 880-0834 Miyazaki, Japan
4
Department of General Internal Medicine, Tenri Hospital, 632-8552 Nara, Japan
5
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 951-8520 Niigata, Japan
6
Department of Rheumatology, Niigata Rheumatic Center, 957-0054 Niigata, Japan
*Correspondence: yuji0516@med.kindai.ac.jp (Yuji Nozaki)
Front. Biosci. (Landmark Ed) 2023, 28(4), 68;
https://doi.org/10.31083/j.fbl2804068
Submitted: 1 February 2023 | Revised: 21 March 2023 | Accepted: 23 March 2023 | Published: 6 April 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
rheumatoid arthritis
infliximab
blood concentration
therapeutic predictor
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