IMR Press / FBL / Volume 28 / Issue 2 / DOI: 10.31083/j.fbl2802035
Open Access Review
Aquaporins and Neuropathic Pain
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1 Department of Anesthesiology, The Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, China
*Correspondence: (Jing-yan Lin)
Front. Biosci. (Landmark Ed) 2023, 28(2), 35;
Submitted: 13 October 2022 | Revised: 28 November 2022 | Accepted: 8 December 2022 | Published: 24 February 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Neuropathic pain is a chronic secondary pain condition resulting from lesions or diseases of the peripheral or central nervous system (CNS). Neuropathic pain is closely related to edema, inflammation, increased neuronal excitability, and central sensitization caused by glutamate accumulation. Aquaporins (AQPs), mainly responsible for the transport and clearance of water and solute, play important roles in developing CNS diseases, especially neuropathic pain. This review focuses on the interaction of AQPs with neuropathic pain, and the potential of AQPs, especially aquaporins 4, as therapeutic targets.

neuropathic pain
glymphatic system
22SXQT0125/Nanchong Science and Technology Bureau
Fig. 1.
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