IMR Press / FBL / Volume 27 / Issue 9 / DOI: 10.31083/j.fbl2709272
Open Access Original Research
Global Research Trends and Hotspots of Autophagy in Colorectal Cancer: A 20-year Bibliometric Analysis Based on Web of Science
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1 Department of General Surgery, First Medical Center of Chinese PLA General Hospital, 100853 Beijing, China
*Correspondence: 15010112665@163.com (Peng-Yue Zhao); duxiaohui301@sina.com (Xiao-Hui Du)
These authors contributed equally.
Academic Editors: Mario Scartozzi, Eleonora Lai, Andrea Pretta and Dario Spanu
Front. Biosci. (Landmark Ed) 2022, 27(9), 272; https://doi.org/10.31083/j.fbl2709272
Submitted: 12 July 2022 | Revised: 27 August 2022 | Accepted: 29 August 2022 | Published: 29 September 2022
(This article belongs to the Special Issue Advances in Gastrointestinal Cancer Research)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Autophagy plays a pivotal role in the progression and management of colorectal cancer (CRC). Recently, numerous articles focusing on the role of autophagy in CRC have emerged. The present study was conducted to provide a comprehensive analysis of the current state and changing trends in the relationship of autophagy and CRC over the past 20 years. Methods: The Web of Science Core Collection (WOSCC) was utilized to extracted all publications with respect to autophagy and CRC during 2002–2021. The contributions of various countries/regions, institutions and journals in this field were analyzed, moreover, research hotspots and promising future trends predicted through keywords were identified by the online platform of bibliometrics, CiteSpace and VOSviewer. Results: A total of 2418 related publications from 2002 to 2021 were identified and collected. China occupied first place with respect to the number of publications, followed by the USA and South Korea. Shanghai Jiao Tong University published the most papers in this field. Most publications were published in Oncotarget. Additionally, analysis of the keywords identified 4 clusters with various research focuses: “mechanism-related research”, “clinical-related research”, “tumorigenesis research” and “chemotherapy-related research”. The three latest hot keywords in this field were epithelial–mesenchymal transition (EMT), promote and invasion. Conclusions: The number of publications and research interest on autophagy and CRC are increasing annually, and the USA had prominent academic positions in the field. Shanghai Jiao Tong University represents a high level of research and the latest progress in this field can be tracked at Oncotarget. Throughout the research history of autophagy and CRC in the past 20 years, previous studies have mainly concentrated on apoptosis and drug resistance in tumor cells, while EMT in regulating tumorigenesis and development of clinical drugs that inhibit tumor invasion through autophagy may be novel hotspots in the future.

Keywords
autophagy
colorectal cancer
bibliometric analysis
EMT
research hotspots
Funding
81871317/National Natural Science Foundation of China
18CXZ025/Key Project of Military Medical Innovation Program
Figures
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