IMR Press / FBL / Volume 27 / Issue 7 / DOI: 10.31083/j.fbl2707218
Open Access Editorial
Twenty-five Years at the Frontiers of Knowledge: A Quarter-century of “Frontiers in Bioscience”
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1 Department of Immunology, University of Tübingen, D-72072 Tübingen, Germany
2 Health Sciences North Research Institute, Sudbury, ON P3E 5J1, Canada
*Correspondence: (Graham Pawelec)
Front. Biosci. (Landmark Ed) 2022, 27(7), 218;
Submitted: 17 March 2022 | Revised: 28 April 2022 | Accepted: 2 June 2022 | Published: 11 July 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Founded in 1996, Frontiers in Bioscience-Landmark celebrated its 25th Anniversary of continuous publication in 2021. Starting from that year, the journal moved to a fully open access gold format. It was my privilege to assume the role of Editor-in-Chief at that time, and to act as Editor for this Special Issue entitled “Twenty-five years at the frontiers of knowledge: a quarter-century of ‘Frontiers in Bioscience’”. This 25th Anniversary celebratory collection of 22 papers from a wide range of biological science disciplines perfectly illustrates the broad appeal of the Journal as a publication vehicle to disseminate the latest findings in diverse fields. These papers cover a wide range of studies on different species, from insects to amphibians, fish, pigs, rats and humans, originating from many different countries (the US, the UK, Spain, Australia, Italy, China, Korea, Germany, Canada, France etc, but also from low and medium income countries such as Lebanon and Bangladesh). Of the 22 papers, half are original research on highly diverse topics including a detailed analysis of signaling pathways in insect heart development [1], stress management in breast cancer patients [2], regulation of myelopoiesis in zebrafish [3], an analysis of heat shock protein expression in human glioblastomas [4], a new method for screening for human topoisomerase inhibitors using genetically-modified yeast [5], genetic influences on systemic iron levels in humans [6], transcriptomics studies on frog development [7], clinical studies on malnourished children with diarrhoea [8], a theoretical investigation of approaches to characterizing logic operations in model neurons, synapses, and neural circuits [9], the effects of methionine-restricted diets on the growth of pigs [10], and the effects of iron on kidney disease in rats [11]. The other half of the papers are reviews on an equally diverse range of topics, including drugs for Alzheimer’s Disease [12], spheroid cell cultures [13], bioactive polyphenols [14], ribosome evolution [15], purinergic signaling in bone cancer [16], spontaneous regressions in cancer [17], genetic analyses of pituitary cancers [18], pharmacological chaperones [19], drug targeting for SARS-CoV-2 infection [20], calcium signaling in mesenchymal stem cells [21], and relationships between the control of circadian rhythm and neurodegeneration [22]. We sincerely thank all authors and readers for their interest in the Journal and look forward to the next 25 years of exciting advances in the biological sciences and an expanded role for the Journal in the OA publishing landscape.

Author Contributions

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Ethics Approval and Consent to Participate

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This research received no external funding.

Conflict of Interest

The author declares no conflict of interest.

Publisher’s Note: IMR Press stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Nichols R, Bass C, Katanski C. Structure-Activity Relationship Data and Ligand-Receptor Interactions Identify Novel Agonists Consistent with Sulfakinin Tissue-Specific Signaling in Drosophila Melanogaster Heart. Frontiers in Bioscience-Landmark. 2022; 27: 150.
Ream M, Saez-Clarke E, Taub C, Diaz A, Frasca D, Blomberg BB, et al. Brief Post-Surgical Stress Management Reduces Pro-Inflammatory Cytokines in Overweight and Obese Breast Cancer Patients Undergoing Primary Treatment. Frontiers in Bioscience-Landmark. 2022; 27: 148.
Meier AB, Basheer F, Sertori R, Laird M, Liongue C, Ward AC. Granulocyte Colony-Stimulating Factor Mediated Regulation of Early Myeloid Cells in Zebrafish. Frontiers in Bioscience-Landmark. 2022; 27: 110.
Alberti G, Campanella C, Paladino L, Porcasi R, Bavisotto CC, Pitruzzella A, et al. The chaperone system in glioblastoma multiforme and derived cell lines: diagnostic and mechanistic implications. Frontiers in Bioscience-Landmark. 2022; 27: 097.
Seddek A, Madeira C, Annamalai T, Mederos C, Tiwari PB, Welch AZ, et al. A Yeast-Based Screening System for Differential Identification of Poisons and Suppressors of Human Topoisomerase i. Frontiers in Bioscience-Landmark. 2022; 27: 093.
Chedid P, Salami A, Ibrahim M, Visvikis-Siest S, El Shamieh S. The association of vascular endothelial growth factor related SNPs and circulating iron levels might depend on body mass index. Frontiers in Bioscience-Landmark. 2022; 27: 1.
Wang S, Liu L, Shi YB, Jiang J. Transcriptome profiling reveals gene regulation programs underlying tail development in the Ornamented Pygmy frog Microhyla fissipes. Frontiers in Bioscience-Landmark. 2021; 11: 1001–1012.
Islam S, Nasrin N, Tithi NS, Lehmann C, Chisti MJ. Clinical features of pneumonia in severely malnourished children with diarrhoea compared to those without diarrhoea. Frontiers in Bioscience-Landmark. 2021; 10: 717–722.
Woo J, Choi K, Kim SH, Han K, Choi M. Characterization of multiscale logic operations in the neural circuits. Frontiers in Bioscience-Landmark. 2021; 10: 723–739.
Yang Z, Hasan MS, Humphrey RM, Htoo JK, Liao SF. Changes in growth performance, plasma metabolite concentrations, and myogenic gene expression in growing pigs fed a methionine-restricted diet. Frontiers in Bioscience-Landmark. 2021; 9: 413–422.
Bhandari S. Impact of intravenous iron on cardiac and skeletal oxidative stress and cardiac mitochondrial function in experimental uraemia chronic kidney disease. Frontiers in Bioscience-Landmark. 2021; 9: 442–464.
Olloquequi J, Ettcheto M, Cano A, Sanchez-López E, Carrasco M, Espinosa T, et al. Impact of New Drugs for Therapeutic Intervention in Alzheimer’s Disease. Frontiers in Bioscience-Landmark. 2022; 27: 146.
Ferrari M, Cirisano F, Morán MC. Super Liquid-repellent Surfaces and 3D Spheroids Growth. Frontiers in Bioscience-Landmark. 2022; 27: 144.
Chu AJ. Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits. Frontiers in Bioscience-Landmark. 2022; 27: 134.
Caetano-Anollés G, Aziz MF, Mughal F, Koç I, Caetano-Anollés K, Caetano-Anollés D. Recruitment: a Problem of Entangled Temporal Parts. Frontiers in Bioscience-Landmark. 2022; 27: 128.
Tattersall L, Gagui DC, Tippett VL, Latif NBA, Shah KM, Gartland A. A Systematic Review of the Expression, Signalling and Function of P2 Receptors in Primary Bone Cancer. Frontiers in Bioscience-Landmark. 2022; 27: 122.
Žarković N, Jaganjac M, Žarković K, Gęgotek A, Skrzydlewska E. Spontaneous Regression of Cancer: Revealing Granulocytes and Oxidative Stress as the Crucial Double-edge Sword. Frontiers in Bioscience-Landmark. 2022; 27: 119.
Mouchtouris N, Smit RD, Piper K, Prashant G, Evans JJ, Karsy M. A review of multiomics platforms in pituitary adenoma pathogenesis. Frontiers in Bioscience-Landmark. 2022; 27: 077.
Pampalone G, Grottelli S, Gatticchi L, Lombardi EM, Bellezza I, Cellini B. Role of misfolding in rare enzymatic deficits and use of pharmacological chaperones as therapeutic approach. Frontiers in Bioscience-Landmark. 2021; 26: 1627–1642.
Kontoghiorghes GJ, Fetta S, Kontoghiorghe CN. The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic. Frontiers in Bioscience-Landmark. 2021; 26: 1723–1736.
Wang L, Roger S, Yang XB, Jiang LH. Role of the store-operated Ca2+ channel in ATP-induced Ca2+ signalling in mesenchymal stem cells and regulation of cell functions. Frontiers in Bioscience-Landmark. 2021; 12: 1737–1745.
Maiese K. Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm. Frontiers in Bioscience-Landmark. 2021; 9: 614–627.
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