Academic Editor: Ranieri Bizzarr
Background: Drosophila
Phosphatase of Regenerating Liver-1 (PRL-1) is the only homolog of the mammalian
PRLs with which it shares high sequence and structural similarities. Whilst PRLs
are most notable for their high expression in malignant cancers and related
promotion of cancer progression, the specific biological functions of the PRLs
remain largely elusive. Methods: Here, using a gain-of-function
approach, we found that PRL-1 functions during wing vein
development in Drosophila melanogaster (Drosophila). Overexpression of Drosophila PRL-1
caused dose-dependent wing vein proliferation. Results: Genetic
screening of the main TGF-