IMR Press / FBL / Volume 27 / Issue 4 / DOI: 10.31083/j.fbl2704133
Open Access Original Research
Autoantibodies to Tumor Necrosis Factor in Patients with Active Pulmonary Tuberculosis
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1 Laboratory of Molecular Immunology, Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology" (RIFCI), 630099 Novosibirsk, Russia
2 First Therapy Department, Federal State Budgetary Institution “Novosibirsk Research Institute of Tuberculosis", Ministry of Health of Russian Federation, 630099 Novosibirsk, Russia
*Correspondence: sennikovsv@gmail.com (Sergey V. Sennikov)
Academic Editor: Hongwei Yao
Front. Biosci. (Landmark Ed) 2022, 27(4), 133; https://doi.org/10.31083/j.fbl2704133
Submitted: 23 November 2021 | Revised: 15 March 2022 | Accepted: 17 March 2022 | Published: 20 April 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Tumor necrosis factor (TNF) plays an important role in immune responses to the causative agent of tuberculosis, Mycobacterium tuberculosis. Additionally, TNF can also mediate many negative disease manifestations. The aim of this study was to assess the contribution of anti-TNF autoantibodies to the pathogenesis of active pulmonary tuberculosis (TB). Methods: The levels of anti-TNF autoantibody classes and subclasses were determined by applying enzyme-linked immunosorbent assays (ELISAs). The levels of TNF and of its soluble receptors were also evaluated using commercial ELISA kits. Results: The levels of both types of soluble TNF receptors were lower patients with TB than in healthy donors. Patients with TB had higher titers of immunoglobulin (Ig)G class and IgG3 subclass anti-TNF autoantibodies in comparison with healthy donors. Patients who had a disseminated TB infection had higher TNF level and IgG, IgG1 and IgG3 autoantibody titers compared with patients who had a localized TB infection. Conclusions: Changes in the titers of anti-TNF autoantibody classes and subclasses were noted in patients with TB, suggesting their possible contribution to the disease pathogenesis of TB.

Keywords
anti-cytokine autoantibodies
tumor necrosis factor
pulmonary tuberculosis
enzyme immunoassay
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