IMR Press / FBL / Volume 27 / Issue 2 / DOI: 10.31083/j.fbl2702060
Open Access Original Research
Prognostic value of protein tyrosine kinase 6 overexpression in cancers: a meta-analysis
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1 Department of Obstetrics and Gynecology, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, 07441 Seoul, Republic of Korea
2 Institute of New Frontier Research Team, Hallym University, 24252 Chuncheon, Republic of Korea
3 Division of Hemato-Oncology, Department of Internal Medicine, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, 07441 Seoul, Republic of Korea
4 Departments of Anesthesiology and Pain Medicine, Chuncheon Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, 24253 Chuncheon, Republic of Korea
*Correspondence: nep2n@hallym.or.kr (Hyeong Su Kim); parkst96@naver.com (Sung Taek Park)
Academic Editor: Alessandro Poggi
Front. Biosci. (Landmark Ed) 2022, 27(2), 60; https://doi.org/10.31083/j.fbl2702060
Submitted: 18 November 2021 | Revised: 11 January 2022 | Accepted: 18 January 2022 | Published: 14 February 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Protein tyrosine kinase 6 (PTK6) plays an important role in cell proliferation and differentiation. However, the functions of PTK6 appear highly context-dependent and differ depending on the cell type, as well as its intracellular localization. High PTK6 expression in tumor has been associated with poor pathological features and prognosis in some studies, but other studies have reported opposite results. Therefore, we performed this meta-analysis to derive more precise estimations of the association of PTK6 expression with prognosis and clinicopathological features in cancer patients. Methods: We conducted a literature search in PubMed, Ovid MEDLINE, and MEDLINE databases to cover all articles published until June 2021. All 1475 patients from the eight studies were included in the meta-analysis. Because of heterogeneity in PTK6 expression in non-tumor tissues, the included studies were divided into two subgroups according to PTK expression in non-tumor tissues: the low expression subgroup (LESG) or high expression subgroup (HESG). Results: Patients with high PTK expression showed significantly worse overall survival (OS) in LESG (Hazard Ratio (HR) = 2.53 [95% Confidence Interval (CI), 1.68–3.83], p < 0.0001), but significantly better OS in HESG (HR = 0.56 [95% CI, 0.40–0.78], p = 0.0006). PTK6 expression also showed different associations with clinicopathological features, such as advanced T classification, stage, and differentiation according to PTK6 expression in non-tumor tissues. Conclusions: PTK6 expression in tumor was a prognostic factor in patients with various cancers, but the direction of prognosis differs, depending on the degree of PTK6 expression in non-tumor tissues.

Keywords
PTK6
brk
prognosis
meta-analysis
Figures
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