IMR Press / FBL / Volume 27 / Issue 10 / DOI: 10.31083/j.fbl2710293
Open Access Review
Exosomes as Anticancer Drug Delivery Vehicles: Prospects and Challenges
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1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, 610041 Chengdu, Sichuan, China
2 Clinical Genetics Laboratory, Affiliated Hospital & Clinical Medical College of Chengdu University, 610081 Chengdu, Sichuan, China
*Correspondence: (Wei Gao); (Na Xie)
Academic Editors: Sarah Shigdar and Maryam Nakhjavani
Front. Biosci. (Landmark Ed) 2022, 27(10), 293;
Submitted: 27 July 2022 | Revised: 16 September 2022 | Accepted: 20 September 2022 | Published: 27 October 2022
(This article belongs to the Special Issue Anticancer Drugs)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Exosomes, a subset of extracellular vesicles, are widely present in various body fluids and are involved in mediating intercellular communication. They have received extensive attention as diagnostic markers. The excellent physicochemical and biological properties of exosomes make them great potential drug delivery vehicles for the treatment of cancer and other diseases. However, various challenges need to be addressed for the clinical application of exosomes. This review introduces the biogenesis and uptake of exosomes and compares different approaches for isolation and drug loading, focusing on the application and current challenges of exosomes as drug delivery vehicles in cancer therapy.

drug delivery
2020YFA0509400/National Key R&D Program of China
81972665/National Natural Science Foundation of China
82102738/National Natural Science Foundation of China
ZYGD22007/1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University
Fig. 1.
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