IMR Press / FBL / Volume 27 / Issue 10 / DOI: 10.31083/j.fbl2710291
Open Access Original Research
Correlation Between Low THBS3 Expression in Peripheral Blood and Acute Myocardial Infarction
Yanqiu Chen1,2,3,4,5Heyu Meng1,2,3,4,5Xin Meng1,2,3,4,5Zhaohan Yan1,2,3,4,5Jingru Wang1,2,3,4,5Fanbo Meng1,2,3,4,5,*
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1 Department of Cardiology, China-Japan Union Hospital of Jilin University, 130033 Changchun, Jilin, China
2 Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis, 130033 Changchun, Jilin, China
3 Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, 130033 Changchun, Jilin, China
4 Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, 130033 Changchun, Jilin, China
5 Jilin Provincial Cardiovascular Research Institute, 130033 Changchun, Jilin, China
*Correspondence: (Fanbo Meng)
Academic Editor: Paramjit S. Tappia
Front. Biosci. (Landmark Ed) 2022, 27(10), 291;
Submitted: 6 July 2022 | Revised: 12 September 2022 | Accepted: 21 September 2022 | Published: 27 October 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Thrombospondin (THBS) 3 is an adhesive glycoprotein involved in cell-cell and cell-matrix interactions. The purpose of this study is to determine whether THBS3 expression in peripheral blood can be used as a biomarker to predict the risk of acute myocardial infarction (AMI). Methods: The peripheral blood of 111 patients with stable coronary artery disease (SCAD) and 112 patients with AMI was obtained. The experimental and the control cohorts were the AMI and SCAD groups, respectively. The expression of THBS3 mRNA and protein in both groups was determined using reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assay. Results: THBS3 expression (range) in the peripheral plasma of patients in the AMI group was lower than that of patients in the SCAD group (4.526 (3.748–5.521), 5.511 (4.726–6.334), respectively), which was 0.82 times lower than the control (p < 0.001). Furthermore, THBS3 mRNA level in the peripheral blood mononuclear cells of patients with AMI was 0.47 times lower than that in patients with SCAD (p < 0.05). AMI was associated with fasting blood glucose levels, platelet counts and low THBS3 expression. Logistic regression analysis revealed that decreased expression of THBS3 protein increased the probability of AMI by 4.076 times (p < 0.01). Additionally, high fasting blood glucose and high platelet counts increased the risk of AMI by 2.819 and 6.515 times, respectively (p < 0.05). Conclusions: THBS3 mRNA and protein levels in the peripheral blood of patients in the AMI group were much lower compared with those of patients in the SCAD group. Low THBS3 expression in peripheral blood was related to AMI and was an independent risk factor for AMI. Thus, low THBS3 expression in peripheral blood may be a novel, suitable molecular marker for the early detection of AMI.

low thrombospondin 3 expression
risk factor
acute myocardial infarction
stable coronary artery disease
peripheral blood
2018SCZ008/the Health Commission of Jilin Province
202522YY010774015/The Special Project For the Development of Medical and Health Industry of Jilin Provincial Department of Science and Technology
19SS014/The Double Ten Project of Changchun Science and Technology Bureau
Fig. 1.
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