Academic Editor: Paramjit S. Tappia
Background: Thrombospondin (THBS) 3 is an adhesive glycoprotein
involved in cell-cell and cell-matrix interactions. The purpose of this study is
to determine whether THBS3 expression in peripheral blood can be used as a
biomarker to predict the risk of acute myocardial infarction (AMI).
Methods: The peripheral blood of 111 patients with stable coronary
artery disease (SCAD) and 112 patients with AMI was obtained. The experimental
and the control cohorts were the AMI and SCAD groups, respectively. The
expression of THBS3 mRNA and protein in both groups was determined using
reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent
assay. Results: THBS3 expression (range) in the peripheral plasma of
patients in the AMI group was lower than that of patients in the SCAD group
(4.526 (3.748–5.521), 5.511 (4.726–6.334), respectively), which was 0.82 times
lower than the control (p