IMR Press / FBL / Volume 26 / Issue 9 / DOI: 10.52586/4974
Open Access Review
Advances in the regulation of plant development and stress response by miR167
Xia Liu1,2,†Sheng Huang1,2,†Hongtao Xie2,*
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1 Shandong Provincial Key Laboratory of Plant Stress Research, College of Life Science, Shandong Normal University, 250014 Jinan, Shandong, China
2 Bellagen Biotechnology Co., Ltd., 250000 Jinan, Shandong, China

These authors contributed equally.

Front. Biosci. (Landmark Ed) 2021, 26(9), 655–665;
Submitted: 26 May 2021 | Revised: 13 July 2021 | Accepted: 28 July 2021 | Published: 30 September 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (

MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNA that cleavage mRNA targets in sequence-specific manner or the inhibition of translation, which regulates gene expression at the post-transcriptional level. miRNAs are involved in the regulation of plant growth, metabolism and stress response. miR167 family is one of the highly conserved miRNA families in plants. It functions mainly by regulating the auxin response factors (ARFs) and IAA-Ala resistant3 (IAR3) genes, and participates in regulating the development of roots, stems, leaves and flowers, flowering time, embryonic development, seed development and stress response. Here, we reviewed the biological functions of miR167 family and its target genes in plant growth and development and stress response, and further discussed the application prospect of miR167 in agricultural production. Furthermore, this review provides references for the further study of miR167 family in plants.

Target gene
Biological function
Agricultural production
Fig. 1.
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