Purpose: In the present study, to achieve high paclitaxel (PTX) loading
in a conjugated drug delivery system with minimal long-term side effects, we
formulated a novel degradable stereocomplexed micelle-like particle with a
core-shell structure. Materials and methods: In this system, methoxy
polyethylene glycol (MPEG) acted as the hydrophilic shell, and the stereocomplex
of polylactic acid with PTX (SCPLA-PTX) acted as the hydrophobic core. The
MPEG-SCPLA-PTX micelle-like particles were synthesized via the self-assembly of a
MPEG-poly L-lactic acid (PLLA) copolymer with a PTX-poly
D-lactic acid-PTX copolymer. The resultant copolymers and their
intermediates were characterized using
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Original Research
PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel
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State Key Laboratory of Pollution Control and Resources Reuse, National Engineering Research Center for Organic Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210023 Nanjing, Jiangsu, China
*Correspondence: jiangwei@nju.edu.cn (Wei Jiang)
Front. Biosci. (Landmark Ed) 2021, 26(9), 517–532;
https://doi.org/10.52586/4964
Submitted: 8 July 2021 | Revised: 5 August 2021 | Accepted: 27 August 2021 | Published: 30 September 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Paclitaxel
MPEG-PLLA
Stereocomplex
Nanoparticles
Controllable drug loading
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