IMR Press / FBL / Volume 26 / Issue 11 / DOI: 10.52586/5011
Open Access Article
Appraisal of the antimicrobial and cytotoxic potentials of nanoparticles biosynthesized from the extracts of Pelargonium quercetorum Agnew
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1 Faculty of Health Sciences, Nutrition and Dietetics, Istanbul Gelisim University, 34310 Istanbul, Turkey
2 Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, 38280 Kayseri, Turkey
3 Deparment of Education, Faculty of Biology, Yüzüncüyıl University, 65090 Van, Turkey
4 Department of Pharmacognosy, Gazi University, 06560 Ankara, Turkey
Front. Biosci. (Landmark Ed) 2021, 26(11), 1089–1096; https://doi.org/10.52586/5011
Submitted: 7 June 2021 | Revised: 23 June 2021 | Accepted: 5 July 2021 | Published: 30 November 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract

Aim: The aim of this study is the synthesis of nanosilver particles (AgNPs) from Pelargonium quercetorum Agnew. (Geraniaceae) and evaluation of the antimicrobial and the cytotoxic potential of AgNPs. Methods: The synthesized AgNPs were evaluated for antimicrobial and anticancer efficacy using the minimum inhibition concentration method and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide) assay. Results: The AgNPs inhibited approximately 90% the growth of gram-positive Staphylococcus aureus and gram-negative Esherichia coli and yeast Candida albicans pathogens at a concentration of 500 μg/mL. The synthesized AgNPs showed excellent toxicity in MCF-7 cells, and specifically, pq70 AgNP inhibited the growth of MCF-7 cells by 52% at a concentration of 3.125 μg/mL. Conclusion: It was determined that the AgNPs, which had been synthesized from extracts that contained a high phenolic composition, were smaller in size, and showed high anticancer and antimicrobial properties.

Keywords
Pelargonium quercetorum
Geraniaceae
Silver nanoparticle
Antimicrobial
Cytotoxicity
Figures
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