IMR Press / FBL / Volume 25 / Issue 8 / DOI: 10.2741/4863

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Psychiatric disorders and changes in immune response in labor and postpartum
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1 Department of Psychiatry, Centre of Postgraduate Medical Education, Warsaw, Poland
2 2nd Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland
Front. Biosci. (Landmark Ed) 2020, 25(8), 1433–1461; https://doi.org/10.2741/4863
Published: 1 March 2020
Abstract

Women may present with psychiatric disorders during pregnancy, normal labor, following delivery by caesarean section, or in the postpartum period. The accumulating evidence suggests that these disorders may be due to changes in immune responses. During pregnancy complications such as the prolongation of cervical ripening or descent, placental abruption, premature labor, and preeclampsia increase the risk of postpartum psychiatric disorders. Women may exhibit depression and postpartum psychosis following either normal birth or caesarean section. Since psychiatric disorders like schizophrenia, major depression, and bipolar disorder are associated with both alterations in the immune response and changes in immune cell subpopulations, in this study we have chosen to examine whether the psychiatric disorders in women during labor or postpartum also lead to aberrant immune responses.

Keywords
: Immune system
Inflammation
Placenta
Pregnancy
Labor
Peripartum depression
Perinatal mental health
Postpartum psychosis
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