IMR Press / FBL / Volume 25 / Issue 6 / DOI: 10.2741/4852

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Association of N6-methyladenosine with viruses and virally induced diseases
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1 Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China
2 Fujian Provincial Key Laboratory of Molecular Medicine and Fujian Provincial Key Laboratory of Precision Medicine and Molecular Detection in Universities, Xiamen, China
3 School of Medicine, Huaqiao University, Xiamen, China
Front. Biosci. (Landmark Ed) 2020, 25(6), 1184–1201; https://doi.org/10.2741/4852
Published: 1 March 2020
Abstract

N6-methyladenosine (m6A) modification, which alters gene expression, is the most prevalent internal modification of eukaryotic mRNA. m6A modification is dynamic and reversible that is regulated by three associated protein groups: methyltransferases or writers, demethylases or erasers, and m6A-binding proteins or readers. m6A modification is involved in all phases of RNA life, from RNA folding and structure, stability, splicing, nuclear export, translational modulation to RNA degradation. Recent findings show that the abnormal level of m6A modification causes aberrant expression of important viral genes. Here, we reviewe m6A role in gene expression and its contribution to the development of human viral diseases. Particularly, we would focus on viruses associated with human diseases including HIV-1, IAV, HBV, HCV, EBV and so on to find a novel approach and provide a new sight for the innovative treatment of human viral diseases.

Keywords
N6 methyladenosine (m6A)
Methyltransferases
Demethylases
m6A-binding proteins
Viral diseases
Review
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