IMR Press / FBL / Volume 24 / Issue 3 / DOI: 10.2741/4726

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The mechanism of action of Lipiburn on fat metabolism
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1 Tyjito Biotechnology Ltd., Central, Hong Kong, SAR, China
Send correspondence to: Bakr M. Rabie, Tyjito Biotechnology Ltd., Central, Hong Kong, SAR, China, Tel: 852-90348584 E-mail:
Front. Biosci. (Landmark Ed) 2019, 24(3), 407–414;
Published: 1 January 2019

Paeoniflorin (PF) is the active ingredient in Lipiburn, a fat loss supplement. PF is a component in Paeonia Lactiflora with multiple medicinal uses. Here, we studied the effect of Lipiburn on fat metabolism in differentiated 3T3-L1 adipocytes. Adipocytes exposed to Lipiburn exhibited significant increase in expression of beta-adrenergic receptors, HSL levels, and cAMP and exhibited increase in glycerol release. The data show that Lipiburn affects fat metabolism through the cAMP route by activating HSL which in turn breaks down triglycerides into glycerol and fatty acids.

Paeonia Lactiflora
fat metabolism
3T3-L1 Adipocytes
Figure 1
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