IMR Press / FBL / Volume 24 / Issue 2 / DOI: 10.2741/4724

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Role of microRNAs in the development of hepatocellular carcinoma and drug resistance
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1 Julius L. Chambers Biomedical Biotechnology Research Institute, USA
2 Department of Pharmaceutical Sciences, North Carolina Central University, Durham NC, USA
3 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
*Correspondence: dkumar@nccu.edu (Deepak Kumar)
Front. Biosci. (Landmark Ed) 2019, 24(2), 382–391; https://doi.org/10.2741/4724
Published: 1 January 2019
Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide and has a relatively poor survival rate. Aside from liver transplantation, the most effective and leading curative measure for HCC is the chemotherapeutic agent sorafenib, which is a multikinase inhibitor used for treating late-stage HCC. However, the effects of sorafenib are short-lived because of rapid acquisition of multi-drug resistance (MDR) by tumor cells. MicroRNAs (miRNAs) have emerged as crucial regulatory molecules for almost every biochemical pathway in humans. The progression of HCC and acquired MDR are critically influenced by miRNAs through regulation of key genes in cell regulatory pathways. This review explores the involvement of miRNAs in the development of HCC and their role in key signaling pathways leading to MDR in HCC.

Keywords
Hepatocellular carcinoma
MicroRNAs
Drug resistance
Cancer progression
Cell survival
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