IMR Press / FBL / Volume 23 / Issue 8 / DOI: 10.2741/4660

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Lipid droplet autophagy during energy mobilization, lipid homeostasis and protein quality control

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1 Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032 USA
2 Current address: HHMI and Dept. of Neuroscience, University of Wisconsin, Madison, WI, 53705 USA
Front. Biosci. (Landmark Ed) 2018, 23(8), 1552–1563;
Published: 1 March 2018

Lipid droplets (LDs) have well-established functions as sites for lipid storage and energy mobilization to meet the metabolic demands of cells. However, recent studies have expanded the roles of LDs to protein quality control. Lipophagy, or LD degradation by autophagy, plays a vital role not only in the mobilization of free fatty acids (FFAs) and lipid homeostasis at LDs, but also in the adaptation of cells to certain forms of stress including lipid imbalance. Recent studies have provided new mechanistic insights about the diverse types of lipophagy, in particular microlipophagy. This review summarizes key findings about the mechanisms and functions of lipophagy and highlights a novel function of LD microlipophagy as a mechanism to maintain endoplasmic reticulum (ER) proteostasis under conditions of lipid imbalance.

Lipid Droplets
ER Quality cControl
ATG core proteins
Lipid Imbalance
Lipid Homeostasis
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