IMR Press / FBL / Volume 23 / Issue 4 / DOI: 10.2741/4614

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Gut microbiota – architects of small intestinal capillaries

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1 Center for Thrombosis and Hemostasis (CTH), University Medical Center, Mainz, Germany
2 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
3 German Center for Cardiovascular Research, Partner Site RheinMain, Mainz, Germany
Front. Biosci. (Landmark Ed) 2018, 23(4), 752–766;
Published: 1 January 2018
(This article belongs to the Special Issue Innate immune mechanisms in thrombosis and vascular biology)

The commensal gut microbiota is an environmental factor that exerts manifold effects on host physiology. One obvious trait is the impact of this densely colonized ecosystem on small intestinal mucosal vascularization. At present, the microbiota-triggered signaling pathways influencing small intestinal renewal, angiogenesis, and vascular remodeling are largely unexplored. While the interplay of gut microbial communities with pattern recognition receptors, such as Toll-like receptors, in intestinal homeostasis is increasingly understood, it is unresolved how commensal microbiota affect the signaling pathways responsible for the formation of capillary networks in the intestinal mucosa. It is evident that intestinal vascular remodeling and renewal is disturbed in case of dysbiosis of this densely colonized microbial ecosystem, in particular under conditions of intestinal inflammation, but the effects of individual components of the gut microbiota are elusive. This review article provides an overview on the revealed microbiota-host interactions, influencing angiogenesis and vascular remodeling processes in the small intestine.

Conventionally Raised
Gut Development
Toll-Like Receptors
Endothelial Cells
Inflammatory Bowel Disease
Intestinal Epithelial Cells
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