IMR Press / FBL / Volume 23 / Issue 3 / DOI: 10.2741/4598

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Diet, microparticles and atherothrombosis

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1 ICCC -Biomedical Research Institute Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Spain
2 CiberCV, Institute Carlos III, Barcelona, Spain
Front. Biosci. (Landmark Ed) 2018, 23(3), 432–457; https://doi.org/10.2741/4598
Published: 1 January 2018
Abstract

Cardiovascular disease is the main cause of death worldwide, and is principally caused by atherosclerosis, with subsequent thrombus formation, eventually provoking an acute myocardial infarction or a stroke. The formation and progression of the atherosclerotic plaques responds to multiple factors including certain diets. Intensive research has elucidated the role of diet in cardiovascular disease and has led to public health policies focusing on educating the population on the role of nutrition in cardiovascular health. Compelling evidence shows that a healthy diet, rich in fruit and vegetables with moderate consumption of fish and a low consumption of animal by-products and processed foods, decreases low-grade inflammation and oxidation, leukocyte activation, platelet aggregation and microparticle shedding. Thus, following such a diet decreases the incidence of cardiovascular disease, lowers mortality and delays the progression of atherothrombosis. Identifying novel risk factors for cardiovascular disease and understanding how food impacts on the disease helps in the development of novel preventive measures.

Keywords
Atherosclerosis
Thrombosis
Platelets
Circulating microparticles
Mediterranean diet
Polyphenols
Unsaturated fatty acids
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