IMR Press / FBL / Volume 22 / Issue 5 / DOI: 10.2741/4520

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Mitochondrial transcription in mammalian cells

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1 University of South Alabama, Patt Capps Covey College of Allied Health Professions, Biomedical Sciences Department, 5721 USA Drive N, HAHN 4021, Mobile, AL 36688-0002, USA
2 University of South Alabama, Department of Physiology and Cell Biology, 5151 USA Dr. North, MSB2058, Mobile, AL 36688, USA

Academic Editor: Mikhail F Alexeyev

Front. Biosci. (Landmark Ed) 2017, 22(5), 835–853; https://doi.org/10.2741/4520
Published: 1 January 2017
(This article belongs to the Special Issue Mitochondrial DNA)
Abstract

As a consequence of recent discoveries of intimate involvement of mitochondria with key cellular processes, there has been a resurgence of interest in all aspects of mitochondrial biology, including the intricate mechanisms of mitochondrial DNA maintenance and expression. Despite four decades of research, there remains a lot to be learned about the processes that enable transcription of genetic information from mitochondrial DNA to RNA, as well as their regulation. These processes are vitally important, as evidenced by the lethality of inactivating the central components of mitochondrial transcription machinery. Here, we review the current understanding of mitochondrial transcription and its regulation in mammalian cells. We also discuss key theories in the field and highlight controversial subjects and future directions as we see them.

Keywords
Mitochondrial DNA
Mitochondrial Promoters
Processing
Regulation
TFAM
Transcription
Transcriptome
Review
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