IMR Press / FBL / Volume 22 / Issue 1 / DOI: 10.2741/4469

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The bad, the good and eIF3e/INT6

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1 INSERM U1037, Centre de Recherche en Cancerologie de Toulouse, 2 Avenue Hubert Curien, Toulouse 31100, France
2 Johns Hopkins University, Department of Neurosurgery, Hunterian Brain Tumor Laboratory, 15550 Orleans Street, Baltimore, Maryland 21231, USA
3 Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
Academic Editor:Nicolas L Skuli
Front. Biosci. (Landmark Ed) 2017, 22(1), 1–20; https://doi.org/10.2741/4469
Published: 1 January 2017
(This article belongs to the Special Issue Cancer, lost in translation)
Abstract

Recent research on translation and protein synthesis in several pathologies, including cancer, peripheral artery disease, and wound healing, demonstrates the key role played by translational factors in tumorigenic and angiogenic processes. This review will focus on one specific translational factor, eIF3e also called INT6, the “e” subunit of the translation initiation factor eIF3. INT6/eIF3e has recently been described as a multifunction protein playing a role in translation, protein degradation, DNA repair, nonsense-mediated mRNA decay, cell cycle and control of cell response to low oxygen (hypoxia or ischemia) through modulation of the Hypoxia Inducible Factors (HIFs). Interestingly, INT6/eIF3e is a double-edged swordthat has both oncogenic and tumor suppressive abilities. In addition to its role in tumorigenesis, its silencing has recently been suggested as a potential therapeutic strategy to improve cell survival and function after ischemic injuries. Although a deeper understanding of the molecular mechanisms involved in these pathophysiological functions is essential, particularly to transform the in vitro /in vivo findings into clinical applications, INT6/eIF3e modulation could provide therapeutic benefit for a variety of human diseases such as cancer or vascular diseases.

Keywords
eIF3e
INT6
Translation
Hypoxia Inducible Factors
Cancer
Angiogenesis
Review
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