IMR Press / FBL / Volume 21 / Issue 7 / DOI: 10.2741/4467

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The impact of autophagy on peripheral synapses in health and disease

Show Less
1 Institute of Molecular and Cell Biology, Mannheim University of Applied Science, Paul-Wittsack-Strabe 10, 68163 Mannheim, Germany
2 Interdisciplinary Center for Neuroscience, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg/Germany
3 Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
4 Institute of Biochemistry, Friedrich-Alexander University of Erlangen-Nurnberg, Fahrstrabe 17, 91054 Erlangen, Germany
Academic Editors:Joseph J McArdle, Vishwendra Patel
Front. Biosci. (Landmark Ed) 2016, 21(7), 1474–1487; https://doi.org/10.2741/4467
Published: 1 June 2016
(This article belongs to the Special Issue Molecular basis of synapse homeostasis and disease)
Abstract

Alterations of autophagy have been linked to several peripheral nervous system diseases, such as amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease. Modulation of autophagy by metabolic or pharmacological interventions has been increasingly recognized as a strategy to fight many of these disorders. Cellular processes that are aberrant in case of impaired autophagy and that might lead to these diseases belong to three different categories: (1) clearing of protein aggregates, (2) regulation of vesicle and cargo turnover, and (3) disposal of damaged mitochondria. This review summarizes the present literature that addresses both, the impact and mechanisms of autophagy on the health of the peripheral nervous system and treatment proposals for human disorders associated with impaired autophagy.

Keywords
Review
NMJ
Autophagy
Peripheral Nervous System
Aggresome
Mitophagy
Review
Share
Back to top