IMR Press / FBL / Volume 21 / Issue 6 / DOI: 10.2741/4446

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Physiological conditions influencing regenerative potential of stem cells

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1 Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino, IRCCS, Milan, Italy
2 Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy
Academic Editor:Elena De Falco
Front. Biosci. (Landmark Ed) 2016, 21(6), 1126–1150; https://doi.org/10.2741/4446
Published: 1 June 2016
(This article belongs to the Special Issue Stem cells: in health and diseases)
Abstract

Stem cells are being used in the treatment of cardivovascular diseases. Here, we review the physiologic and pathologic conditions that impact the regenerative potential of stem cells in the treatment of cardiovascular diseases which include the influence of donor age and the presence of metabolic syndromes. We will also discuss strategies such as pretreatment of the recipient tissue or autologous or allogeneic stem cells by growth factors or drugs and by providing a synthetic scaffold and genetic modifications that impact the regenerative potential of stem cells. Finally, we will evaluate the current state of treatment of acute or chronic cardiovascular diseases with allogeneic stem cells.

Keywords
Stem Cells
Mesenchymal Stem Cells
Endothelial Progenitor Cells
Cardiac Regeneration
Heart Failure
Diabetes
Metabolic Syndrome
Aging
Review
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