IMR Press / FBL / Volume 21 / Issue 3 / DOI: 10.2741/4407

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Nature creates, adapts, protects and sustains life using hydrogen sulfide

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1 Frontiers in Bioscience Research Institute in Aging and Cancer, CA, 92618, USA
Academic Editor:Hua Zhang
Front. Biosci. (Landmark Ed) 2016, 21(3), 528–560;
Published: 1 January 2016
(This article belongs to the Special Issue Gaseous transmitters)

Life emerged on Earth in an anaerobic environment, bathed in noxious gases. Among these gases, the role of hydrogen sulfide is significant since this gas, was required as a building block of life, contributed to abiogenic generation of organic compounds that gave rise to life and drove adaptations of life throughout its entire evolutionary path. During evolution, hydrogen sulfide contributed to sustaining life in face of harsh environmental conditions. Modern cells still utilize hydrogen sulfide as a signaling molecule, in pro and anti-inflammatory responses, for acquisition of tolerance against damage, in directing repair responses, as a source of energy and in modifying their genetic makeup and function to acquire a phenotype reminiscent of early life forms.

Hydrogen Sulfide
Stem cells
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