IMR Press / FBL / Volume 21 / Issue 1 / DOI: 10.2741/4382

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Retinopathy of prematurity: an oxidative stress neonatal disease

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1 Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State, University, Johnson City, Tennessee, 37614, USA
Front. Biosci. (Landmark Ed) 2016, 21(1), 165–177;
Published: 1 January 2016

Proteomics is the global study of proteins in an organism or a tissue/fluid and is clinically relevant since most disease states are accompanied by specific alterations in an organism’s proteome. This review focuses on the application of proteomics to neonatology with particular emphasis on retinopathy of prematurity (ROP), which is a disease in which oxidative stress plays a key pathophysiological role. Oxidative stress is a physiologically relevant redox imbalance caused by an excess of reactive oxygen (ROS) or reactive nitrogen oxide species (RNOS). A major conclusion of this review is that proteomics may be the optimal technology for studying neonatal diseases such as ROP, particularly in the setting of a neonatal intensive care unit (NICU). Proteomics has already identified a number of ROP serum biomarkers. This review will also suggest novel therapeutic approaches to ROP and other neonatal oxidative stress diseases (NOSDs) based on a systems medicine approach.

Systems Biology
Premature Infants
Retinopathy Of Prematurity
Vitamin E
Glutathione Peroxidase
Superoxide Dismutase
Single Nucleotide Polymorphism
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