IMR Press / FBL / Volume 2 / Issue 5 / DOI: 10.2741/A229

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Splanchnic vascular control during sepsis and endotoxemia
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1 Department of Surgery, The University of Illinois College of Medicine at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612-7342, USA
2 Departments of Physiology & Biophysics, The University of Illinois College of Medicine at Chicago 835 South Wolcott Avenue, Chicago, IL 60612-7342, USA
Front. Biosci. (Landmark Ed) 1997, 2(5), 72–92; https://doi.org/10.2741/A229
Published: 1 October 1997
Abstract

Endotoxemia and sepsis often result in circulatory derangements which manifest as perfusion maldistributions. It has been widely accepted that the splanchnic circulation decreases in perfusion during advanced septic or endotoxemic states. Impaired perfusion of splanchnic organs may result not only in organ dysfunction but also exacerbations of polymicrobial bacteremia due to intestinal mucosal leakage. Consequently, evaluation of the splanchnic mechanisms of vasoregulation and how perfusion is maintained is vital to any topic concerning the management of the septic patient.

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