IMR Press / FBL / Volume 2 / Issue 4 / DOI: 10.2741/A173

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Role of cholesterol in the regulation of renal phosphate transport
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1 Department of Medicine, The University of Texas Southwestern Medical Center at Dallas, Texas 75216, USA
Front. Biosci. (Landmark Ed) 1997, 2(4), 43–48;
Published: 1 February 1997

The kidney plays a critical role in the regulation of inorganic phosphate (Pi) homeostasis through changes in the proximal tubular apical membrane Na-dependent Pi (Na/Pi) transport activity. In response to alterations in dietary Pi intake and during the aging process, changes in renal Na/Pi transport activity are inversely correlated with apical membrane cholesterol content. Cholesterol regulates Na/Pi transport activity by fluidity-dependent and fluidity-independent mechanisms, including regulation of Na/Pi protein transcription, synthesis, and trafficking to and from the plasma membrane.

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