IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4296

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

ADAMTS-18: A metalloproteinase with multiple functions

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1 Department of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA
2 Department of Medicine, SUNY Stony Brook University, Stony Brook, NY 11794, USA
3 Department of Orthopaedic Surgery, Shandong University School of Medicine, Jinan, Shandong 250012, PR China
4 Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Academic Editor:Chuan-ju Liu
Front. Biosci. (Landmark Ed) 2014, 19(8), 1456–1467; https://doi.org/10.2741/4296
Published: 1 June 2014
Abstract

ADAMTS-18 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which are known to play important roles in development, angiogenesis and coagulation; dysregulation and mutation of these enzymes have been implicated in many disease processes, such as inflammation, cancer, arthritis and atherosclerosis. Mutations of ADAMTS-18 have been linked to abnormal early eye development and reduced bone mineral density. In this review, we briefly summarize the structural organization and the expression of ADAMTS-18. We will also focus on the emerging role of ADAMTS-18 in several pathophysiological conditions which include: hematological diseases, tumorgenesis, osteogenesis, eye-related diseases, central nervous system disorders, and last but not least a research perspective of ADAMTS-18 and its potential as a promising diagnostic and therapeutic target.

Keywords
ADAMTS-18
Alternative forms
Hemostasis
Tumor suppresser gene
Bone
Eye
Central nervous system
Review
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